The route starts from the parking lot of Pescegallo (M 1,473); from here you need to reach - to the right - trail number 148 that climbs through the woods. The trail reaches and passes Lago di Trona, which is at an altitude of 1,805 meters above sea level, then follow the path that - near a hut - climbs the scree towards Lago dell'Inferno (M 2,072), another artificial basin. The Pizzo is now in sight, but still far away: you are about halfway through the itinerary. The route continues, beyond the dam, to reach Bocchetta di Varrone (M 2130), then on the trail to the left along the lakeshore. Trail number 118 follows the slope and climbs to Bocchetta di Piazzocco (M 2,252). The route - in its final stretch, with an altitude difference still of about 300 meters - climbs the long ridge of the pizzo, passes a last plateau and some simple slabs. The summit of Pizzo dei Tre Signori is at 2554 meters altitude. The view is over all the Alps, up to Monte Rosa and the Matterhorn; to the south the Valsassina with the Grigne, Milan, the Lombard plain and the first Tuscan-Emilian Apennines hills.
The return follows the same itinerary.